DelveInsight’s “Myelodysplastic Syndrome with Excess Blasts2 Market Insight, Epidemiology And Market Forecast – 2032” report provides an in-depth understanding of the Myelodysplastic Syndrome with Excess Blasts-2 market, including historical and forecasted epidemiology, current treatment approaches, emerging therapies, and future trends across the 7MM. The report covers the study period from 2019 to 2032, with detailed market forecasts, offering valuable insights for healthcare stakeholders, pharmaceutical companies, and investors interested in this specialized hematological market segment.
MDS-EB2, an advanced subtype of myelodysplastic syndrome (MDS), is characterized by an increased number of blasts in the bone marrow or blood and is associated with an increased risk of progression to acute myeloid leukemia (AML) compared to other MDS subtypes. The MDS-EB2 market is expected to grow significantly by 2032 with a decent CAGR. The total myelodysplastic syndrome market size was more than USD 2.8 billion across the 7MM in 2023. Furthermore, the US holds the largest market share among the 7MM. This trend is expected to continue, mainly due to higher disease awareness, favorable reimbursement, and early adoption of innovative therapies.
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The epidemiological analysis presented in the report delivers comprehensive insights into the historical and forecasted MDS-EB2 patient pool across the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan. MDS-EB2 primarily affects older adults, with a male predominance. Recent classification systems have recognized the biological and clinical overlap between MDS-EB-2 and acute myeloid leukemia, leading to significant changes in how these patients are categorized.
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The DelveInsight report also analyses the current and evolving MDS-EB2 treatment landscape. Current therapeutic approaches involve complex, multifaceted strategies tailored to individual patient profiles. Treatment decisions typically consider factors such as the patient’s age, overall health status, comorbidities, and specific disease characteristics. The current MDS-EB2 treatment landscape primarily consists of hypomethylating agents (HMAs) like VIDAZA (Bristol-Myers Squibb) and DACOGEN (Janssen), which have shown efficacy in improving blood counts and potentially delaying progression to AML.
The MDS-EB2 treatment pipeline is advancing rapidly, with several innovative therapies in late-stage clinical development. The most anticipated development is the completion of the phase III VERONA trial (NCT04401748) evaluating venetoclax in combination with azacitidine for high-risk MDS, including MDS-EB2, with primary results expected soon. Sabatolimab, an immune checkpoint inhibitor, also showed encouraging but not statistically significant improvements in response rates and duration in phase II trials for higher-risk MDS, with ongoing evaluation. Additionally, liposomal daunorubicin-cytarabine (CPX-351) is being tested in combination with stem cell transplantation to reduce residual disease.
These emerging therapies target various pathways involved in disease pathogenesis, potentially offering more effective and less toxic treatment options compared to conventional approaches. The report provides detailed insights into these pipeline drugs, including their mechanisms of action, clinical trial status, and anticipated launch timelines, enabling stakeholders to assess their potential impact on the future treatment landscape.
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Looking ahead, the MDS-EB2 market is expected to evolve substantially as research advances our understanding of disease pathogenesis, leading to more personalized treatment approaches and improved patient outcomes. The integration of novel biomarkers for patient stratification and the development of combination therapies targeting specific molecular alterations represent promising directions for future research and market growth. These advancements are expected to address current unmet needs and have a significant impact on the management of this challenging hematological condition.
Table of Contents
1. Key Insights
2. Myelodysplastic Syndrome with Excess Blasts2 Executive Summary
3. Myelodysplastic Syndrome with Excess Blasts2 Competitive Intelligence Analysis
4. Myelodysplastic Syndrome with Excess Blasts2 Market Overview at a Glance
5. Myelodysplastic Syndrome with Excess Blasts2 Market Disease Background and Overview
6. Myelodysplastic Syndrome with Excess Blasts2 Patient Journey
7. Myelodysplastic Syndrome with Excess Blasts2 Epidemiology and Patient Population
8. Myelodysplastic Syndrome with Excess Blasts2 Treatment Algorithm, Current Treatment, and Medical Practices
9. Myelodysplastic Syndrome with Excess Blasts2 Unmet Needs
10. Key Endpoints of Myelodysplastic Syndrome with Excess Blasts2 Treatment
11. Myelodysplastic Syndrome with Excess Blasts2 Marketed Products
12. Myelodysplastic Syndrome with Excess Blasts2 Emerging Therapies
13. Myelodysplastic Syndrome with Excess Blasts2: Seven Major Market Analysis
14. Attribute analysis
15. 7MM: Myelodysplastic Syndrome with Excess Blasts2 Market Outlook
16. Myelodysplastic Syndrome with Excess Blasts2 Market Access and Reimbursement Overview
17. Myelodysplastic Syndrome with Excess Blasts2 KOL Views
18. Myelodysplastic Syndrome with Excess Blasts2 Market Drivers
19. Myelodysplastic Syndrome with Excess Blasts2 Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
23. About DelveInsight
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Myelodysplastic Syndrome with Excess Blasts2 Pipeline Insight
Myelodysplastic Syndrome with Excess Blasts2 Pipeline Insight provides comprehensive insights about the MDS-EB2 pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the Myelodysplastic Syndrome companies, including Sunesis Pharmaceuticals, Astellas Pharma Global Development Inc., Jazz Pharmaceuticals, Celgene, Access Pharmaceuticals Inc., AbbVie Inc., Bristol-Myers Squibb, Novartis AG, Takeda Pharmaceutical Company Limited, Amgen Inc., Onconova Therapeutics, Astex Pharmaceuticals, Inc., Otsuka Pharmaceutical Co. Ltd., Lupin Pharmaceuticals, Hikma Pharmaceuticals PLC, Cipla Limited, Dr. Reddy’s Laboratories Ltd., Sun Pharmaceutical Industries Limited, FibroGen Inc., Aprea Therapeutics, Bayer AG, Celator Pharmaceuticals, Crystal Genomics Inc., Geron Co., Mylan NV, Sandoz Inc., Syros Pharmaceuticals, Teva Pharmaceutical Industries Ltd., Acceleron Pharma Inc., Agios Pharmaceuticals Inc., Incyte Corporation, Array Biopharma Inc., and MEI Pharma Inc., among others.
About DelveInsight
DelveInsight is a leading market research and consulting firm specializing in disease-specific insights and therapeutic market analysis. Their reports integrate real-world data, clinical trial findings, and expert interviews to deliver comprehensive industry intelligence.
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